Para médicos · reumatologia
Resumos de artigos, podcasts e newsletters sobre Uveíte, para atualização médica.
A newsletter apresenta os destaques do EULAR 2026, focando em novas evidências para o tratamento da Artrite Reumatoide e Espondiloartrite Axial. São discutidos estudos inovadores sobre o uso de tocilizumabe na depressão inflamatória, o efeito da tirzepatida no ácido úrico e a eficácia do upadacitinibe após falha terapêutica. O conteúdo também aborda o papel da IA no suporte a pacientes com esclerose sistêmica e um caso clínico de Doença de Vogt-Koyanagi-Harada.
Abstract Introduction Juvenile idiopathic arthritis–associated uveitis (JIA-U) is an important cause of childhood and adult visual impairment. Advances in surveillance approaches and treatment have improved outcomes, yet delayed detection and treatment-refractory disease remain substantial challenges. This review summarises recent developments across disease stratification, imaging, pharmacologic management, and psychosocial support, following the natural history of disease from inception to adulthood. Main body Risk-stratified screening based on antinuclear antibody status, JIA subtype, and age at arthritis onset is now standard, but many cases present outside screening windows. Novel biomarkers, including S100A8/A9, S100A12, and genetic risk alleles, offer promise for earlier identification. Ocular imaging modalities such as anterior segment optical coherence tomography and optical coherence tomography angiography enable objective, child-friendly detection of inflammation and subclinical vascular changes, potentially extending specialist-level assessment to community settings. Early initiation of immunomodulatory therapy in children with JIA is now prevalent care, reducing uveitis incidence and improving outcomes in childhood, although the consequence may be new challenges later in the lifecourse. Anti-tumour necrosis factor therapy has changed the management of JIA-U for the better, although precision strategies, such as anti-drug antibody monitoring, dose individualisation, and tapering approaches are needed to further optimise care. For refractory disease, biologics and other emerging therapies are under investigation, but new therapeutic targets are needed. Beyond ocular health, JIA-U imposes a heavy psychosocial burden on children and families, exacerbated by treatment side-effects and frequent medical visits. Validated tools, such as the EYE-Q questionnaire, and co-developed educational and self-management resources will be key to addressing mental health and quality-of-life concerns. Conclusion JIA-U remains a lifelong, vision-threatening condition despite advances in screening, diagnostics, and treatment. Integration of biomarker-based risk stratification, advanced imaging, and precision pharmacology
A newsletter destaca que a sequência terapêutica na osteoporose é crítica, revelando que o uso de teriparatida após romosozumabe pode resultar em perda de força óssea estrutural. Além disso, fornece uma revisão detalhada sobre a sarcoidose extrapulmonar, enfatizando a importância da triagem cardíaca e ocular sistemática e o papel de exames avançados como PET-CT e RM cardíaca no manejo da doença.
A newsletter discute o potencial do baricitinibe em pacientes com uveíte associada à AIJ refratários a biológicos e destaca como a mudança para equações de função pulmonar neutras em relação à raça altera significativamente a classificação de gravidade na esclerose sistêmica. Além disso, aborda evidências recentes sobre a eficácia do adalimumabe na Síndrome de Behçet e os benefícios metabólicos e inflamatórios dos agonistas de GLP-1 na artrite reumatoide.