Spatial transcriptomics reveals an SPP1-centered immune–fibrotic axis associated with fibrosis-related tissue remodeling in IgG4-related disease
IgG4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by progressive organ damage; however, the spatial organization linking immune dysregulation to fibrotic remodeling remains incompletely understood. In this study, we performed spatial transcriptomic an…