Peripheral blood UBA1 variant burden predicts poor outcomes in VEXAS syndrome: a nationwide prospective study.
Vacuole, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome (VS) is a severe autoinflammatory disease caused by acquired pathogenic UBA1 variants and is associated with high mortality. This study aimed to identify predictors of poor outcomes in VEXAS syndrome. We co…