Do people with tophaceous gout require more allopurinol for good clinical outcomes? Analysis of two randomized controlled trials with allopurinol dose escalation.
OBJECTIVE: Prescribing advice recommends higher doses of allopurinol in tophaceous gout "to accomplish full control of gout and to lower serum uric acid to normal or near-normal levels". The aim of this study was to determine whether outcomes differ between individuals with and…