Association of Epigenetic Trajectory With Development of Clinical Rheumatoid Arthritis in Individuals With Anti–Citrullinated Protein Antibody Positivity: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP‐RA)
Objective The presence of anti–citrullinated protein antibodies in the absence of clinical inflammatory arthritis identifies individuals at risk for rheumatoid arthritis (RA). We examined whether epigenetic remodeling of DNA methylation distinguishes those who ultimately develop…