CD14+CD16+ monocyte-derived TREM2 macrophages promote lung fibrosis in systemic sclerosis-interstitial lung disease.
Scar-associated macrophages (SAMs), defined by triggering receptor expressed on myeloid cells 2 (TREM2) and/or glycoprotein-NMB (GPNMB) expression, have been implicated in lung fibrosis. This study investigated the characteristics and functional roles of SAMs in lung tissues fro…