Advanced Bayesian BMD-Derived Genome-Wide Polygenic Scores Enhance Clinical FRAX-Based Fracture Risk Prediction in Postmenopausal Women.
Current fracture prediction tools, including the Fracture Risk Assessment Tool (FRAX), rely primarily on clinical risk factors and bone mineral density measurements, yet omit genetic information. Given osteoporosis's substantial heritability (estimated at 50-80%), excluding gene…