DNA methylation profiling reveals distinct epigenetic clusters and suggests epigenetic patterns associated with sex and disease activity in childhood‐onset lupus
Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs, with childhood‐onset SLE (cSLE) typically presenting a more severe course and greater genetic risk than adult‐onset SLE. Although DNA methylation plays a key role in lupus pat…