MTHFR risk alleles associate with Th17 immunity and spinal damage in axial spondyloarthritis.
MTHFR polymorphisms regulate homocysteine metabolism, yet their role in clinical heterogeneity, immune dysregulation, and treatment outcomes in axial spondyloarthritis (axSpA) remains undefined. This cross-sectional study included 180 axSpA patients and a retrospective TNF inhib…