Age-stratified treatment response in rheumatoid arthritis: a systematic review, meta-analysis, and integrated genetic and single-cell evidence implicating IL6R/TYK2 signaling
Background Late-onset rheumatoid arthritis (LORA, onset ≥ 60 years, a threshold commonly adopted based on accelerated immunosenescence at this age) represents a growing clinical challenge as population’s age, yet therapeutic outcomes in this subgroup remain inadequately cha…